Endocrine Abstracts

Laminitis, an inflammatory condition of the sensitive and specialised architecture (the laminae) in the equine hoof, can be induced by over-ingestion of non-structural carbohydrates (NSC) from spring/summer pasture. Some equids that are predisposed to laminitis appear to share characteristics described in human patients with metabolic syndrome, such as vascular dysfunction, obesity, development of an inflammatory profile and insulin resistance. We investigated whether adipose ...

Laminitis, an inflammatory condition of the sensitive and specialised architecture (the laminae) in the equine hoof, can be induced by over-ingestion of non-structural carbohydrates (NSC) from spring/summer pasture. Some equids that are predisposed to laminitis appear to share characteristics described in human patients with metabolic syndrome. We investigated if adipose tissue from laminitis prone equids (LP) functions differently from non-laminitis prone equids (NL), by exam...

Objective: Chorionic gonadotrophin (CG) is a hormone induced during terminal differentiation of trophoblast cells that significantly influences pregnancy outcome. The TGFβ superfamily SMAD2/3 pathway regulates placental function but the activity of the alternative pathway through SMAD1/5/8 in the placenta is unknown. This study investigated the role of BMP4 signalling through SMAD1/5 in terminal differentiation of primary chorionic gonadotrophin-secreting trophoblast cell...